Nährstoffsupplemente - Möglichkeiten und Grenzen. Teil 6: Sicherheit und mögliche Risiken

verfasst von

A. Ströhle, A.  Hahn

Abstract

Due to the precautionary principle in consumer protection, thresholds for long-term safety of nutrients have to be defined. Three toxical indicators are of interest: lowest observed adverse effect level (LOAEL); no observed adverse effect level (NOAEL) und tolerable level of upper intake (UL). An uptake of a nutrient within the range of UL is without side effects even on the basis of long term consumption. The UL can be used to derive maximum levels for nutrients in food supplements. In general, vitamins can be regarded as safe nutrients except for vitamin A. Adverse effects only occur at excessive intake far beyond the recommended daily allowances. In contrast, the range of safe intake for minerals, especially trace elements, is much smaller. This can be seen clearly in the case of selenium. In order to prevent severe selenium deficiency a plasma concentration of > 0.25 μmol/l (> 20 μg/l) must be reached. To minimize cancer risk a plasma concentration of 1.5 μmol/l (120?μg/l) is needed. First signs of selenium intoxications occur at plasma levels over 250 μg/l. It is the dose that makes the preventive effect and the poison as well.

Organisationseinheit(en)

Institut für Lebensmittelwissenschaft und Humanernährung
Abteilung Ernährungsphysiologie und Humanernährung

Typ

Artikel

Journal

Medizinische Monatsschrift fur Pharmazeuten

Band

37

Seiten

249-256

Anzahl der Seiten

8

ISSN

0342-9601

Publikationsdatum

07.2014

Publikationsstatus

Veröffentlicht

ASJC Scopus Sachgebiete

Pharmakologie (medizinische)

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen