Efficacy of goldenberry in improving obesity-induced hemoglobin conformational structure changes in wistar rats

A biophysical perspective

verfasst von

Sherif A. Abdelmottaleb Moussa, Samir W. Aziz, Samir A. Bashandy, Marawan Abd elbaset, Noha A. Abd El-Latif, Sherif M. Afifi, Tuba Esatbeyoglu, Sayed A. El Toumy, Josline Y. Salib

Abstract

The relationship between obesity and the conformational structure of hemoglobin (Hb) has not been extensively investigated. This study aims to elucidate the dielectric parameters that distinguish the Hb molecule under obese conditions and following treatment with goldenberry (GB) extract, compared to a control group. The dielectric parameters analyzed include the loss factor (D), relaxation time (τ), dielectric increment (Δε), relative permittivity (έ), dielectric loss (ε"), conductivity (σ), and Cole-Cole parameters (α), measured across a frequency range of 20 Hz to 3 MHz. Significant differences in dielectric parameters were observed between obese rats and those treated with GB extract. Obese rats exhibited higher dielectric values compared to the control group, while rats treated with low and high doses of GB extract showed marked changes in Hb conformational structure. This study highlights the potential of dielectric parameters as biophysical markers for detecting hemoglobin conformational changes. Furthermore, it suggests that dielectric behavior could serve as an early indicator for assessing the severity of obesity and its related complications.

Organisationseinheit(en)

Institut für Lebensmittelwissenschaft und Humanernährung
Molekulare Lebensmittelchemie und -entwicklung

Externe Organisation(en)

National Research Center, Cairo
Università di Bologna

Typ

Artikel

Journal

Heliyon

Band

10

ISSN

2405-8440

Publikationsdatum

30.11.2024

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Allgemein

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1016/j.heliyon.2024.e40189 (Zugang: Offen)