Impact of chocolate liquor on vascular lesions in apoE-knockout mice
- verfasst von
- N. Yazdekhasti, C. Brandsch, F. Hirche, J. Kühn, A. Schloesser, Tuba Esatbeyoglu, P. Huebbe, S. Wolffram, G. Rimbach, G. I. Stangl
- Abstract
Cocoa polyphenols are thought to reduce the risk of cardiovascular diseases. Thus, cocoa-containing foods may have significant health benefits. Here, we studied the impact of chocolate liquor on vascular lesion development and plaque composition in a mouse model of atherosclerosis. Apolipoprotein E (apoE)-knockout mice were assigned to two groups and fed a Western diet that contained 250 g/kg of either chocolate liquor or a polyphenol-free isoenergetic control paste for 16 weeks. In addition to fat, protein, and fibers, the chocolate liquor contained 2 g/kg of polyphenols. Compared with the control group, mice fed the chocolate liquor had larger plaque areas in the descending aorta and aortic root, which were attributed to a higher mass of vascular smooth muscle cells (VSMCs) and collagen. Vascular lipid deposits and calcification areas did not differ between the two groups. The aortic tissue level of interleukin-6 (IL-6) mRNA was 5-fold higher in the mice fed chocolate liquor than in the control mice. Chocolate-fed mice exhibited an increased hepatic saturated to polyunsaturated fatty acid ratio than the controls. Although the chocolate liquor contained 14 μg/kg of vitamin D
2, the chocolate liquor-fed mice did not have measurable 25-hydroxyvitamin D
2 in the serum. These mice even showed a 25% reduction in the level of 25-hydroxyvitamin D
3 compared with the control mice. Overall, present data may contribute to our understanding how chocolate constituents can impact vascular lesion development.
- Organisationseinheit(en)
-
Institut für Lebensmittelwissenschaft und Humanernährung
Molekulare Lebensmittelchemie und -entwicklung
- Typ
- Artikel
- Journal
- Clinical Science
- Band
- 131
- Seiten
- 2549-2560
- Anzahl der Seiten
- 12
- ISSN
- 0143-5221
- Publikationsdatum
- 15.10.2017
- Publikationsstatus
- Veröffentlicht
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Allgemeine Medizin
- Ziele für nachhaltige Entwicklung
- SDG 3 – Gute Gesundheit und Wohlergehen
- Elektronische Version(en)
-
https://doi.org/10.1042/cs20170279 (Zugang:
Geschlossen)
