Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations

verfasst von

Astrid M. Drotleff, C. Bohnsack, Inga Schneider, Andreas Hahn, Waldemar Ternes

Abstract

Tocotrienols are members of the vitamin E family thought to have hypocholesterolaemic, anti-cancer, and neuroprotective properties. We compared the bioavailability and pharmacokinetics of a single oral dose of 450. mg total tocotrienols from α-tocotrienol-rich barley oil and γ-tocotrienol-rich palm oil (both also low in tocopherols) in seven healthy male human subjects 0-24. h post-dose. The maximum α-tocotrienol plasma concentration (22.57. ±. 2.84. mg/L, 2.1. ±. 0.3. h) was significantly ( p<. 0.001) higher for barley oil than for palm oil (5.25. ±. 0.99. mg/L, 2.3. ±. 0.6. h). The area under the curve (0-24. h) of total (α-, β-, γ-, δ-) tocotrienols was significantly ( p<. 0.001) (2.6fold) higher in the barley oil group, where the total (0-24. h) urinary metabolites carboxyethyl-hydroxychromans (CEHC) and carboxymethylbutyl-hydroxychromans (CMBHC) were also significantly ( p<. 0.05) (1.2fold) higher (163.9. ±. 19.2. μmol). Thus, due to its high proportion of α-tocotrienol, which is known for its preferential absorption, the barley oil formulation was superior to the commercial palm oil formulation. This provides support for the application of tocotrienols from barley oil in the functional foods field.

Organisationseinheit(en)

Institut für Lebensmittelwissenschaft und Humanernährung
Abteilung Ernährungsphysiologie und Humanernährung

Externe Organisation(en)

Stiftung Tierärztliche Hochschule Hannover

Typ

Artikel

Journal

Journal of functional foods

Band

7

Seiten

150-160

Anzahl der Seiten

11

ISSN

1756-4646

Publikationsdatum

2014

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Lebensmittelwissenschaften, Medizin (sonstige), Ernährung und Diätetik

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1016/j.jff.2014.01.001 (Zugang: Geschlossen)