Magnesium Bioavailability and Tolerability Do Not Differ between Two Supplements with Different Release Properties
- verfasst von
- Theresa Greupner, Inga Schneider, S. Gellert, Andreas Hahn
- Abstract
Magnesium (Mg
2+) is one of the most frequently supplemented micronutrients. Due to possible gastrointestinal side effects, the European Food Safety Authority and the Institute of Medicine set the upper intake level for Mg
2+ from supplements to 250 and 350 mg, respectively. Nevertheless, systematic data concerning the tolerability of Mg
2+ supplements are scarce. The aim of the study was to directly compare the bioavailability and tolerability of two 500 mg Mg
2+ supplements in a crossover study with duplicate determination. The different release properties were either a direct release (one phase) or a delayed release of the second half (two phases). An open-label, controlled trial with a crossover design, duplicate determination, and one-week washout phases was conducted. The participants ingested the test product after overnight fasting. Blood samples were taken at baseline and after 1, 2, 3, 4, 6, and 8 hours, and urine was collected over a period of 24 hours. The participants were on standardized nutrition during all examination days. There were no significant differences between the test products regarding 24-hour renal Mg
2+ excretion and area under the curve of serum Mg
2+ levels for 8 hours. Both test products were well tolerated with a very low frequency of gastrointestinal adverse effects and no significant differences between the test products. The Mg
2+ bioavailability did not differ between the test products. The supplements examined had the same good tolerability. Both test products are therefore suited to enhance Mg
2+ supply without relevant side effects.
- Organisationseinheit(en)
-
Institut für Lebensmittelwissenschaft und Humanernährung
Abteilung Ernährungsphysiologie und Humanernährung
- Typ
- Artikel
- Journal
- Journal of Dietary Supplements
- Band
- 17
- Seiten
- 454-466
- Anzahl der Seiten
- 13
- ISSN
- 1939-0211
- Publikationsdatum
- 03.07.2020
- Publikationsstatus
- Veröffentlicht
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Lebensmittelwissenschaften, Ernährung und Diätetik, Pharmakologie (medizinische)
- Elektronische Version(en)
-
https://doi.org/10.1080/19390211.2019.1629146 (Zugang:
Geschlossen)
