Plasma malondialdehyde and risk of new-onset diabetes after transplantation in renal transplant recipients: A prospective cohort study

verfasst von
Manuela Yepes-Calderón, Camilo G. Sotomayor, António W. Gomes-Neto, Rijk O.B. Gans, Stefan P. Berger, G. Rimbach, Tuba Esatbeyoglu, Ramón Rodrigo, Johanna M. Geleijnse , Gerjan J. Navis, Stephan J.L. Bakker
Abstract

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. We included 516 RTR (51 ± 13 years-old, 57% male). Median plasma malondialdehyde (MDA) was 2.55 (IQR, 1.92-3.66) µmol/L. During a median follow-up of 5.3 (IQR, 4.6-6.0) years, 56 (11%) RTR developed NODAT. In Cox proportional-hazards regression analyses, MDA was inversely associated with NODAT, independent of immunosuppressive therapy, transplant-specific covariates, lifestyle, inflammation, and metabolism parameters (HR, 0.55; 95% CI, 0.36-0.83 per 1-SD increase;

p < 0.01). Dietary antioxidants intake (e.g., vitamin E, α-lipoic acid, and linoleic acid) were effect-modifiers of the association between MDA and NODAT, with particularly strong inverse associations within the subgroup of RTR with relatively higher dietary antioxidants intake. In conclusion, plasma MDA concentration is inversely and independently associated with long-term risk of NODAT in RTR. Our findings support a potential underrecognized role of oxidative stress in post-transplantation glucose homeostasis.

Organisationseinheit(en)
Institut für Lebensmittelwissenschaft und Humanernährung
Externe Organisation(en)
University Medical Center Groningen (UMCG)
Universidad de Chile
Wageningen University and Research
Typ
Artikel
Journal
Journal of Clinical Medicine
Band
8
ISSN
2077-0383
Publikationsdatum
04.2019
Publikationsstatus
Veröffentlicht
Peer-reviewed
Ja
ASJC Scopus Sachgebiete
Allgemeine Medizin
Ziele für nachhaltige Entwicklung
SDG 3 – Gute Gesundheit und Wohlergehen
Elektronische Version(en)
https://doi.org/10.3390/jcm8040453 (Zugang: Offen)
https://doi.org/10.15488/10958 (Zugang: Offen)