Impact of nutrition on short-term exercise-induced sirtuin regulation

Vegans differ from omnivores and LACTO-OVO vegetarians

verfasst von

Arne Björn Potthast, Josefine Nebl, Paulina Wasserfurth, S. Haufe, J. Eigendorf, Andreas Hahn, Anibh Das

Abstract

Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.

Organisationseinheit(en)

Abteilung Ernährungsphysiologie und Humanernährung
Institut für Lebensmittelwissenschaft und Humanernährung
Institut für Sportwissenschaft

Externe Organisation(en)

Medizinische Hochschule Hannover (MHH)

Typ

Artikel

Journal

NUTRIENTS

Band

12

ISSN

2072-6643

Publikationsdatum

05.04.2020

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Lebensmittelwissenschaften, Ernährung und Diätetik

Elektronische Version(en)

https://doi.org/10.3390/nu12041004 (Zugang: Offen)