Lipid-based nanodelivery systems of curcumin: Recent advances, approaches, and applications

authored by

Asli Can Karaca, Atefe Rezaei, Muhammad Qamar, Elham Assadpour, Tuba Esatbeyoglu, Seid Mahdi Jafari

Abstract

Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented.

Organisation(s)

Institute of Food Science and Human Nutrition
Molecular Food Chemistry and Food Development
Institute of Food and One Health

External Organisation(s)

Istanbul Technical University
Isfahan University of Medical Sciences
Bahauddin Zakariya University
Gorgan University of Agricultural Sciences and Natural Resources (GUASNR)

Type

Article

Journal

Food Chemistry

Volume

463

ISSN

0308-8146

Publication date

11.09.2024

Publication status

E-pub ahead of print

Peer reviewed

Yes

ASJC Scopus subject areas

Analytical Chemistry, Food Science

Electronic version(s)

https://doi.org/10.1016/j.foodchem.2024.141193 (Access: Closed)