Effect of gastric acid resistant coating of fish oil capsules on intestinal uptake of eicosapentaenoic acid and docosahexaenoic acid

authored by: Inga Schneider, Jan Philipp Schuchardt, Henrike Meyer, Andreas Hahn
Abstract: Fish oil capsules with gastric acid resistant coatings have been shown to lower undesirable side effects. We compared the eicosapentaenoic acid (EPA). +. docosahexaenoic acid (DHA) uptake from uncoated and coated fish oil capsules. In a double-blinded crossover trial 12 healthy young men (mean age 31. years) were randomized to 1680. mg EPA. +. DHA as triacylglycerols in uncoated or coated fish oil capsules. Fatty acid levels were analyzed in plasma phospholipids at baseline and 2, 4, 6, 8, 24, 48 and 72. h after capsule ingestion. Statistical group comparisons on the basis of area under the curve values revealed no significant differences for EPA, DHA and total n-3 fatty acid levels between the different capsule formulations. In conclusion, this nutrikinetic study indicates that coating of fish oil capsules with a gastric acid resistant layer has no influence on the bioavailability of EPA. +. DHA.
Organisation(s): Institute of Food Science and Human Nutrition
Nutrition Physiology and Human Nutrition Section
Type: Article
Journal: Journal of functional foods
Volume: 3
Pages: 129-133
No. of pages: 5
ISSN: 1756-4646
Publication date: 04.2011
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Food Science, Medicine (miscellaneous), Nutrition and Dietetics
Electronic version(s): https://doi.org/10.1016/j.jff.2011.03.001 (Access: Unknown)