Long-chain omega-3 fatty acids improve brain function and structure in older adults

authored by

A Veronica Witte, Lucia Kerti, Henrike M Hermannstädter, Jochen B Fiebach, Stephan J Schreiber, Jan Philipp Schuchardt, Andreas Hahn, Agnes Flöel

Abstract

Higher intake of seafish or oil rich in long-chain omega-3 polyunsaturated fatty acids (LC-n3-FA) may be beneficial for the aging brain. We tested in a prospective interventional design whether high levels of supplementary LC-n3-FA would improve cognition, and addressed potential mechanisms underlying the effects. Sixty-five healthy subjects (50-75 years, 30 females) successfully completed 26 weeks of either fish oil (2.2 g/day LC-n3-FA) or placebo intake. Before and after the intervention period, cognitive performance, structural neuroimaging, vascular markers, and blood parameters were assayed. We found a significant increase in executive functions after LC-n3-FA compared with placebo (P = 0.023). In parallel, LC-n3-FA exerted beneficial effects on white matter microstructural integrity and gray matter volume in frontal, temporal, parietal, and limbic areas primarily of the left hemisphere, and on carotid intima media thickness and diastolic blood pressure. Improvements in executive functions correlated positively with changes in omega-3-index and peripheral brain-derived neurotrophic factor, and negatively with changes in peripheral fasting insulin. This double-blind randomized interventional study provides first-time evidence that LC-n3-FA exert positive effects on brain functions in healthy older adults, and elucidates underlying mechanisms. Our findings suggest novel strategies to maintain cognitive functions into old age.

Organisation(s)

Institute of Food Science and Human Nutrition
Nutrition Physiology and Human Nutrition Section

External Organisation(s)

Charité - Universitätsmedizin Berlin

Type

Article

Journal

Cerebral Cortex

Volume

24

Pages

3059-3068

No. of pages

10

ISSN

1047-3211

Publication date

11.2014

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Cellular and Molecular Neuroscience, Cognitive Neuroscience

Electronic version(s)

https://doi.org/10.1093/cercor/bht163 (Access: Unknown)