Effect of two different multimicronutrient supplements on vitamin D status in women of childbearing age: a randomized trial
- authored by
- S. Pilz, Andreas Hahn, C. Schön, M. Wilhelm, R. Obeid
- Abstract
The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25 (OH) D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25 (OH) D. 196 participants completed the trial. Increases in 25 (OH) D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25 (OH) D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25 (OH) D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient.
- Organisation(s)
-
Institute of Food Science and Human Nutrition
Nutrition Physiology and Human Nutrition Section
- External Organisation(s)
-
Medical University of Graz
BioTeSys GmbH Esslingen
Ulm University of Applied Sciences
Aarhus University
- Type
- Article
- Journal
- NUTRIENTS
- Volume
- 9
- ISSN
- 2072-6643
- Publication date
- 04.01.2017
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Food Science, Nutrition and Dietetics
- Electronic version(s)
-
https://doi.org/10.3390/nu9010030 (Access:
Open)
