Bedeutung von L-Arginin für die Gefäßgesundheit

authored by

A. Ströhle, H. von Bibra, A.  Hahn

Abstract

Endothelial dysfunction, characterized by a disturbed vascular NO metabolism, represents a key point in atherogenesis. Modern antiatherogenic therapies improve NO availability within the endothelium. As L-arginine acts as the substrate of endo-thelial nitric oxide synthase (eNOS), arginine supplementation can enhance NO formation. Actually, L-arginine at appropriate dosage (6-8 g/day) improves endothelial function and lowers blood pressure. However, beneficial efects can only be expected in individuals with pronounced endothelial dysfunction and/or individuals with an absolute (patients with hemodialysis) or relative (patients with elevated ADMA levels) arginine deficiency. Whether L-arginine delays progression of atherosclerotic lesions and lowers cardiovascular morbidity and mortality is unknown.

Organisation(s)

Institute of Food Science and Human Nutrition
Nutrition Physiology and Human Nutrition Section

External Organisation(s)

Städtisches Klinikum München

Type

Article

Journal

Medizinische Monatsschrift fur Pharmazeuten

Volume

39

Pages

515-520

No. of pages

6

ISSN

0342-9601

Publication date

12.2016

Publication status

Published

ASJC Scopus subject areas

Pharmacology (medical)