Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease

authored by

A.A. Kayacelebi, J. Willers, V.V. Pham, Andreas Hahn, J.Y. Schneider, S. Rothmann, J.C. Frölich, D. Tsikas

Abstract

Elevated circulating concentrations of total L-homocysteine (thCys) and free asymmetric dimethylarginine (ADMA) are long-established cardiovascular risk factors. Low circulating L-homoarginine (hArg) concentrations were recently found to be associated with increased cardiovascular morbidity and mortality. The biochemical pathways of these amino acids overlap and share the same cofactor S-adenosylmethionine (SAM). In the present study, we investigated potential associations between hArg, L-arginine (Arg), ADMA and thCys in plasma of patients suffering from rheumatoid arthritis (RA), coronary artery disease (CAD) or peripheral artery occlusive disease (PAOD). In RA, we did not find any correlation between ADMA or hArg and thCys at baseline (n = 100) and after (n = 83) combined add-on supplementation of omega-3 fatty acids, vitamin E, vitamin A, copper, and selenium, or placebo (soy oil). ADMA correlated with Arg at baseline (r = 0.446, P < 0.001) and after treatment (r = 0.246, P = 0.03). hArg did not correlate with ADMA, but correlated with Arg before (r = 0.240, P = 0.02) and after treatment (r = 0.233, P = 0.03). These results suggest that hArg, ADMA and Arg are biochemically familiar with each other, but unrelated to hCys in RA. In PAOD and CAD, ADMA and thCys did not correlate.

Organisation(s)

Institute of Food Science and Human Nutrition
Nutrition Physiology and Human Nutrition Section
Institute of Technical Chemistry

External Organisation(s)

Hannover Medical School (MHH)
Zentrum Pharmakologie und Toxikologie

Type

Article

Journal

AMINO ACIDS

Volume

47

Pages

1885-1891

No. of pages

7

ISSN

0939-4451

Publication date

28.09.2015

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Biochemistry, Clinical Biochemistry, Organic Chemistry

Electronic version(s)

https://doi.org/10.1007/s00726-015-1915-3 (Access: Closed)