A combination of palm oil tocotrienols and citrus peel polymethoxylated flavones does not influence elevated LDL cholesterol and high-sensitivity C-reactive protein levels

authored by

Jan Philipp Schuchardt, S. Heine, A. Hahn

Abstract

Background/Objectives:Lipid-lowering and anti-inflammatory effects have been individually described for tocotrienols (TTs) and polymethoxylated flavones (PMFs). This study investigated low-density lipoprotein-cholesterol (LDL-C)- and high-sensitivity C-reactive protein (hsCRP)-reducing effects of combined TT-PMF treatment in low doses in hypercholesterolemic individuals with subclinical inflammation.Subjects/Methods:In the double-blind, placebo-controlled study, 240 Caucasians with LDL-C ≥3.36 mmol/l and hsCRP ≥1 mg/l were enrolled and randomized into group S1 (12 mg/day TT and 103 mg/day PMF), group S2 (27 mg/day TT and 32 mg/day PMF) or placebo.Results:Twenty-three subjects dropped out of the study, 13 were excluded from the analysis because of lack of compliance. A total of 204 subjects per-protocol analysis were included. After 12 weeks of treatment, no significant differences in LDL-C levels (primary outcome) were observed between groups. LDL-C levels significantly decreased in all intervention groups (S1: -5.2%, S2: -4.8% and P: -4.2%). Total cholesterol and hsCRP (secondary outcome) did not change significantly.Conclusions:PMF-TT supplements had no effect beyond that of placebo on elevated LDL-C and hsCRP levels.

Organisation(s)

Institute of Food Science and Human Nutrition
Nutrition Physiology and Human Nutrition Section

Type

Article

Journal

European Journal of Clinical Nutrition

Volume

69

Pages

1209-1214

No. of pages

6

ISSN

0954-3007

Publication date

01.11.2015

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Medicine (miscellaneous), Nutrition and Dietetics

Electronic version(s)

https://doi.org/10.1038/ejcn.2015.44 (Access: Open)